Medicinal uses, phytochemistry and pharmacology of picralima. International journal of pharmacy publishes effects of. Apocynaceae is a west african plant with varied applications in african folk medicine. Files are available under licenses specified on their description page. The ethanolic fruit extract of picralima nitida stapf which proved to be a potent spasmogen in vitro was tested in pregnant female sprague dawley rats. From the foregoing, it is obvious that several works have diversely investigated the effects of. This work was aimed to determine the toxicological parameters of the aqueous. International research journal of pharmaceutical and applied sciences irjpas available online at. Ive been in limbo on whether or not to order more kratom, or say goodbye forever if the worst case scenario happens.
Access is allocated within two business days of purchase and lasts one year. Picralima nitida in the germplasm resources information network grin, u. Picralima nitida, biochemical parameter, sickle cell blood, methanol extract and fraction, abstract the study determined the effects of methanol extract and fractions of p. All structured data from the file and property namespaces is available under the creative commons cc0 license. Optimization of corrosion inhibition of picralima nitida.
It is an opiate, but its action is principally on the kappa opioid receptor, as such it is not a plant that gives you direct spiritual experience in the way that opium or morphine does. Plant extract as biodegradable inhibitor for zinc in. Antioxidant and antidiabetic profiles of two african medicinal plants. Usda, ars, germplasm resources information network. Evaluation of the antimicrobial property of the stem bark. Picralima nitida is a medicinal plant with diverse end uses. The methanol m extract of the fruitrinds of picralima nitida pn was analyzed phytochemically and evaluated for its toxicity effect in wistar rats. In vitro and in vivo antitrypanosomal effects of methanol. This plant is widely distributed throughout africa forest regions. Male rats were divided into five groups for acute and subacute study.
Optimization of polycondensation process of alkyd resin. Scholars research library chemical compositions of. Picralima nitida commonly known as akuamma is a tree which has been used primarily for its high potential effect in herbal medicines. This data descriptor announces the submission to public repositories of the monoterpene indole alkaloid database miadb, a cumulative collection of.
It is a commonly used herbal remedy in west africa. In traditional african medicine, picralima nitida seeds are used for the treatment of malaria and diarrhoea. The objective of this study is to evaluate the toxicological. Fifteen successfully mated female rats were divided into three groups of five animals each. Groups 1 and 2 received intraperitoneal injection of 50 and 500 mgkg body weight of the extract dissolved in distilled water, respectively, on. Picralima nitida seed extract pne has aphrodisiac and contraceptive effect. This page was last edited on 16 october 2018, at 10. Please note that this is a trial program and may end.
Picralima nitida seeds can be dried and stored for 0. Picralima nitida akuamma seeds akuammine seeds from. Aqueous extract of seeds of picralima nitida was used to evaluate its protective effect on dexamethasoneinduced insulinresistance in rats. The seeds are crushed or powdered and taken orally, and are traditionally mainly used for the treatment of malaria, diarrhoea, and as a painkiller. Pdf constituents of picralima nitida display pronounced. Pdf medicinal uses, phytochemistry and pharmacology of. Toxicopathological evaluation of picralima nitida seed. Picralima nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory effects along with analgesia in animal studies. This study reports the in vitro and in vivo antishigellosis activity of the methanol extract of this plant on rats.
Insecticides resistance and the corresponding health and environmental challenges that arises as a result of the use of synthetic chemical based insecticides prompts the search for better alternative control measures which are more effective. Picralima nitida is a widely used medicinal plant in west africa for treating malaria, diarrhea and inflammation. Collected mass spectrometry data on monoterpene indole. Emergence of insecticide resistant strains of the mosquitoes poses a serious threat and hence calls for alternative control measures. Picralima nitida stapf is a bonafide member of the family apocynaceae and restricted in distribution to african rain forest regions. The extract cleared the parasite completely from the t. Picralima nitida is a medicinal plant with diverse end uses keay, 1989 extracts from its seeds, fruit rind and stem bark demonstrated antimalarial activity iwu. All parts of the plant are bitter throughout its distribution area. The size and length of the combs of white leghorn dayold chicks treated with testosterone 0. Phytochemical screening and toxicological profile of. Research article open access the antishigellosis activity.
Medicinal uses, phytochemistry and pharmacology of picralima nitida. I wanted to test out a post kratom ban scenario by taking akuamma as a. Picralima nitida apocynaceae family is one of such medicinal plants. Picralima nitida is a common species of the african forest zone, and is not threatened by genetic erosion. The dried akuamma seeds from this plant are used in traditional remedies throughout west africa, particularly in ghana. Acute and subacute effects of aqueous extract of picralima. Its fruits are ovoid and yellowish at maturity adjanohoun et al. Five new monoterpene indole alkaloids 15, including four serpentininerelated bisindoles and one alstonine derivative monomer, have been isolated from the aerial parts of picralima nitida. The fruit pulp, possesses hypoglycaemic properties. Pseudoakuammigine, an alkaloid from picralima nitida seeds, has antiinflammatory and analgesic actions in rats chemosystematic value of cyclopeptide alkaloids from heisteria nitida olacaceae original mechanisms of antipsychotic action by the indole alkaloid alstonine picralima nitida. Pdf screening of the seed of picralima nitida for hypoglycaemic. The plant has wide varied applications in nigeria herbal medicine. Picralima is a plant genus in the family apocynaceae, first described as a genus in 1896. Picralima in world checklist of selected plant families.
Picralima nitida is a member of the family apocynaceae. But it heals and is useful as a means of healing as such it is worthwhile including it. Picralima nitida akuamma commonly called asewa in ibibio dialect is a rainforest tree rich in alkaloids occurring in african forest region. It is a wildly grown tree and widely distributed in the tropical rain forests of africa. Picralima nitida is an entirely glabrous shrub of 310 m high.
Apocynaceae and order gentianales is a widely distributed medicinal plant that grows in the tropical rainforests of africa, as homesteads or bushes 4, 5. Several of these were shown to bind to opioid receptors with weak affinity in vitro, and two compounds, akuammidine and. Various parts of the plant have been employed ethnomedicinally as remedy for fever, hypertension, jaundice, dysmenorrheal, gastrointestinal disorders and malaria. Media in category picralima nitida the following 12 files are in this category, out of 12 total. Effects of ethanolic fruit extract of picralima nitida. However, in some areas with a high human population pressure, the species has become scarce because of its use as. Akuamma seed powder are often related to kratom because of its alkaloid shares similarities with kratom active alkaloids mitragynine. Pdf an investigation of the lethality of picralima. Constituents of picralima nitida display pronounced inhibitory. Constituents of picralima nitida display pronounced inhibitory activities against asexual erythrocytic forms of plasmodium falciparum in vitro. In vitro uterotonic effects of ethanolic fruit extract of. After having lost access to kratom leaf for research in my local area, i searched for a natural product similar to kratom and found picralima nitida seeds, better known as akuamma.
Toxicopathological evaluation of picralima nitida seed aqueous. When fully grown, it is about 20 m high with white flowers and large paired fruits. Evaluation of picralima nitida acute toxicity in the mouse koffi ng, emma aa, stephane dk abstract picralima nitida is a small tree used in a wide range by traditional medicine to cure various pathologies. In vitro uterotonic effects of ethanolic fruit extract of picralima nitida. Pdf the seed extract of picralima nitida was screened for hypoglycaemic activity. Picralima nitida apocynaceae and sonchus oleraceus asteraceae. Evaluation of antiplasmodial activity of ethanolic seed. The results of this study showed that the essential oils of picralima nitida seeds were predominated by monoterpenes and sesquiterpenes and with high possibility of finding applications in therapy as an anticancer agent and antifungal. International research journal of pharmaceutical and. Their structures were elucidated by analysis of their hrms and nmr spectroscopic data, and their absolute configurations were deduced from the comparison of experimental and simulated ecd spectra. It is a native to western africa particularly ghana, ivory coast and nigeria. Akuammine is the most abundant active alkaloid found in the seeds from the tree picralima nitida, commonly known as akuamma. All reports are erowid and you agree not to download or analyze the report data without contacting erowid center and receiving permission first. The methanol extract of the root of picralima nitida showed the highest in vivo antitrypanosomal activity at 100 mgkg body weight.
It is known as limeme congo, eban, obero gabon, erin yoruba, osuigwe igbo, bamborutuk, eban cameroon. The antiplasmodial activities of organic and aqueous extracts from the west african plant picralima nitida. The board of trustees of the royal botanic gardens, kew. It is used as a painkiller and for its antipyretic, antidiabetic and antiinflammatory effects. Medicinal uses, phytochemistry and pharmacology of. The basic fraction bf of the methanol extract of the stem bark of picralima nitida family apocynaceae exhibited significant antimicrobial activity against a wide range of gram.
These seeds are known to contain kratomlike alkaloids, so i obtained 100 grams of ground akuamma seed powder from an online vendor and started a new study. Evaluation of picralima nitida acute toxicity in the mouse. However, the oil should be scientifically evaluated so as to. Pdf evaluation of antiplasmodial activity of ethanolic seed extract. Assessment of an ethanolic seed extract of picralima. Fruits of picralima nitida were cut into small pieces and dried under sunlight and subsequently pulverized with manual grinder into coarse powder. To investigate the effect of pne on reproductive hormones. Larvicidal activity of picralima nitida, an approach in. Picralima nitida is a west african plant with varied applications in african folk medicine. Ethanol, benzene, chloroform and aqueous cold and hot extracts of picralima nitida seed, stembark and root were tested against five bacterial strians using. Akuamma seed powder report picralima nitida ive been off kratom for about 44 days. It contains only one known species, picralima nitida, native to tropical africa.
Chronic oral consumption of ethanolic extract of picralima nitida. Journal of ethnopharmacology 111 2007 464467 evaluation of antiplasmodial activity of ethanolic seed extract of picralima nitida jude e. Picralima nitida stapf apocynaceae is a medicinal plant used traditionally in cameroon to cure various ailments such as gastrointestinal disorders and dysentery. General 1, first times 2, preparation recipes 30, alone 16 copyrights. Toxicopathological evaluation of picralima nitida seed aqueous extract in wistar rats. Firstly, picralima nitida plant is a tree that can reach a height of 35 meters, but is usually less. Evaluation of antiplasmodial activity of ethanolic seed extract of picralima nitida author links open overlay panel jude e. Research article antidiabetic property of picralima nitida.
Manual of the materia medica, gave 61 possible remedies for cough eccles. The available evidences in this study suggest that aqueous extract of p. Picralima nitida seeds contain a mixture of alkaloids producing antipyretic and antiinflammatory. Durand family apocynaceae isolectotype of picralima klaineana pierre family apocynaceae previous. Chapter 7 alkaloids of picralima nitida pdf free download. The study aims to evaluate the blood sugar reduction activity of seed oil extracted from the seed of picralima nitida and to compare its intraperitonial and oral administration with that of seed.
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